Let’s not mince words: Women are often faced with sexist or obnoxious questions and comments. Celebrities and politicians, especially, contend with interviews that involve totally inappropriate questions on a regular basis (of the would you ask a man this? variety). But most women know that you don’t have to take these kinds of questions lying down. Stand up for yourself and talk back, delivering a coup de grace that’s heavy on wit, not snarling anger. Here, 12 times women had the absolutely perfect reply to an unfortunate situation, from Lauren Conrad to Hillary Clinton.